Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14.
نویسندگان
چکیده
Analysis of complex formation between amyloid-β fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11-14 mediates zinc-induced dimerization of amyloid-β and may serve as a potential drug target for preventing development and progression of Alzheimer's disease.
منابع مشابه
Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain.
Zinc-induced aggregation of the amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease (AD). Recently it was shown that phosphorylation of Aβ at Ser8 promotes the formation of toxic aggregates. In this work, we have studied the impact of Ser8 phosphorylation on the mode of zinc interaction with the Aβ metal-binding domain 1-16 using isothermal titration calorimetry, elect...
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ورودعنوان ژورنال:
- Molecular bioSystems
دوره 7 4 شماره
صفحات -
تاریخ انتشار 2011